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Koli Aesthetics
Polynucleotides
Polynucleotides are advanced skin-regenerating injectables with the aim to improve skin quality, including hydration, texture and elasticity
Polynucleotides At A Glance
Discomfort
Mild
Results Seen
Gradual
Longevity
6-12 Months*
Downtime
Minimal
Polynucleotides are naturally occuring molecules composed or long chains of nucleotides, which are the building blocks of DNA and RNA.
At Koli Aesthetics, we use Rejuran®, a polynucleotide injectable developed by South Korean biotechnology company PharmaResearch. Rejuran contains purified polynucleotides derived from salmon DNA, processed using the company’s patented DNA Optimizing Technology (DOT™)
The treatment has multiple benefits, including stimulating fibroblasts in our skin (to aid with collagen production), improving tissue firmness, enhancing hydration and helping with minimising scars. It also has anti-inflammatory properties! It is incredible at restoring skin structure, supporting tissue regeneration, and promoting a healthier, more radiant completion. Polynucleotides work on skin function and quality, making them an excellent option for anyone seeking natural, regenerative results.
01
Natural Looking Results
Providing subtle and natural-looking results and enhancing the skin's appearance.
02
Minimal Downtime
Most patients can return to their normal activities immediately after treatment.
03
Versatile
Can be used on the face, neck and body. Some are suitable for around the eyes.
04
Minimally Invasive With Little Downtime
Return to your daily activities 24-48 hours after treatment.
The Benefits Of Polynucleotides
FAQs (Polynucleotides)
Rejuran can be used anywhere on the face, neck and eyes. It can also be used to help improve scars. We will assess the area you are concerned about and explain which options may be suitable.
Polynucleotides are a regenerative treatment. Results are gradual and appear over time. Some patients pay notice improvements in hydration and skin quality as early as 2-4 weeks, with continued improvement in firmness, texture and elasticity over the following months.
Results typically last between 6–12 months. A course of treatments is usually recommended initially, followed by maintenance sessions to sustain long-term skin regeneration and quality.
Discomfort is minimal. Very fine needles are used, and a topical numbing cream is applied prior. Most patients describe the sensation as mild and very manageable.
Side effects are generally mild and temporary. You may experience slight redness, swelling, tenderness, or small bumps at the injection sites, which usually settle within 24–48 hours.
Yes. Plinest® and Vitaran work by stimulating your skin’s own repair and regeneration processes, meaning results develop gradually and look completely natural, with no added volume or overfilled appearance.
Downtime is minimal. Most clients return to normal activities immediately, with any mild redness or swelling resolving within a day or two.
A consultation is required for all new patients to the clinic. If you have been seen my our other practitioners working in the clinic, a consultation will still be required if visiting Sarah for aesthetics treatments for the first time.
If you are an existing patient but wish to discuss alternative treatments, please book a consultation so we can assess your suitability and talk through treatment options.
To book a consultation or treatment appointment, please visit our Booking page.